Endocrine Abstracts

Introduction: Increased capacity for glucocorticoid regeneration in subcutaneous adipose tissue (SAT) by 11β-hydroxysteroid dehydrogenase-1 (11HSD1) is associated with obesity and associated risk factors. We hypothesised that down-regulation of SAT 11HSD1 and/or glucocorticoid receptor-α (GRα) may explain differences in body fat distribution and metabolic risk between black and white women. The study aimed to compare the expression of 11HSD1 and glucocorticoid r...

We have previously reported the following metabolic abnormalities were common in 203 adult patients with CAH: obesity (41%), hypercholesterolemia (46%), insulin resistance (29%), osteopenia (40%) and osteoporosis (7%) (Arlt et al. JCEM 2010 95 5110–21). The CAH patients were taking different glucocorticoid therapies at various doses (n=196): hydrocortisone (n=25 M, 26 W), prednisolone (n=21M,67W), dexamethasone (n=15M,22W) or comb...

Background: No treatment guidelines exist for CAH adults. To address this we have undertaken a cross-sectional analysis of health status.Patients and methods: Three hundred and eighty patients from 17 tertiary centres were contacted: 203 (53%) consented (138 f, 65 m, median age 34 (range 18–69) years). One hundred and sixty-five had classic and 34 non-classic CAH. The UK prevalence is 3591 adults >18 years therefore the capture rate was 5.7%. Re...